Viral Animal Model. Intravenous inoculation of the rhesus macaque with lcmv leads to clinical signs of disease including febrile temperatures, anorexia, diarrhea, orbital hemorrhage, and shock [ 49 ]. The animal models are important for both the fundamental research and drug discovery of coronavirus.
Experience predicts that there will be a pandemic for sure although the time is unknown. A better understanding of their pathogenesis and mechanisms of transmission requires animal models that accurately reproduce these aspects of the disease. Many cell culture and animal models have been used to study hepatitis b virus (hbv) replication and its effects in the liver;